VEGFR2 blockade inhibits glioblastoma cell proliferation by enhancing mitochondrial biogenesis.

Min GuoJunhao ZhangJiang HanYingyue HuHao NiJuan YuanYang SunMeijuan LiuLifen GaoWangjun LiaoChunhong MaYaou LiuShuijie Li Chunyang Li

Published in: Journal of translational medicine (2024)

VEGFR2 blockade inhibits glioblastoma progression via AKT-PGC1α-TFAM-mitochondria biogenesis signaling cascade, suggesting that VEGFR2 intervention might bring additive therapeutic values to anti-glioblastoma therapy.

Keyphrases

cell proliferation
vascular endothelial growth factor
randomized controlled trial
oxidative stress
signaling pathway
skeletal muscle
cell cycle
endothelial cells