RGS4 negatively modulates Nociceptin/Orphanin FQ opioid receptor signaling: implication for L-Dopa-induced dyskinesia.

C A PisanòD MercatelliM MazzocchiA BrugnoliI MorellaS FasanoN T ZaveriR BrambillaG W O'KeeffeR R NeubigMichele Morari

Published in: British journal of pharmacology (2021)

RGS4 physiologically inhibits NOP receptor signaling. CCG-203920 enhanced NOP responses and improved the antidyskinetic potential of NOP receptor agonists, mitigating the effects of striatal RGS4 upregulation occurring during dyskinesia expression.

Keyphrases

poor prognosis
chronic pain
high glucose
diabetic rats
pain management
cell proliferation
long non coding rna
parkinson disease
drug induced
risk assessment