Statistical considerations when estimating time-saving treatment effects in Alzheimer's disease clinical trials.
Guoqiao WangGary CutterNeil P OxtobyGuogen ShanWhedy WangBrian MangalYijie LiaoJorge J Llibre-GuerraYan LiChengjie XiongEric McDadePaul DelmarRandall J BatemanLon SchneiderPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
We explore the statistical considerations of the current method for estimating time savings. We proposed alternative methods that provide time savings estimations based on the observed absolute differences. By using various methods, a more comprehensive estimation of time savings can be achieved.