Energy balance and body composition after switch between integrase strand transfer inhibitors and doravirine among people with HIV.
Kristine M ErlandsonRuda MohawecheMary MorrowSamantha MawhinneyVincent KhuuMallory BoydAshok BalasubramanyamEdward L MelansonJordan E LakePublished in: The Journal of antimicrobial chemotherapy (2023)
Among PWH with >10% weight gain on an INSTI, switch to doravirine was associated with a trend towards decreases in 24 h EE, weight, trunk fat mass and fat-free mass. Observed changes were not significant, but suggest a mild weight-suppressive effect of doravirine among PWH.
Keyphrases
- weight gain
- body composition
- body mass index
- birth weight
- adipose tissue
- resistance training
- bone mineral density
- weight loss
- antiretroviral therapy
- hiv positive
- hiv infected
- human immunodeficiency virus
- fatty acid
- hiv testing
- hiv aids
- physical activity
- men who have sex with men
- lower limb
- south africa
- postmenopausal women
- preterm birth
- gestational age