A Systematic Review and Meta-regression Analysis on the Impact of Increasing IgG Trough Level on Infection Rates in Primary Immunodeficiency Patients on Intravenous IgG Therapy.

Jian Lynn LeeNoraida Mohamed ShahMohd Makmor-BakryFarida Hanim IslahudinHamidah AliasLokman Mohd NohShamin Mohd Saffian

Published in: Journal of clinical immunology (2020)

This meta-analysis concludes that titrating the IgG trough levels up to 960 mg/dL progressively reduces the rate of infections, and there is less additional benefit beyond that. Further studies to validate this result are required before it can be used in clinical practice.

Keyphrases

systematic review
clinical practice
end stage renal disease
ejection fraction
case control
peritoneal dialysis
prognostic factors
high dose
randomized controlled trial
low dose
cell therapy