Effects of therapeutic plasma exchange on the endothelial glycocalyx in septic shock.

Klaus StahlUta Carola HillebrandYulia KiyanBenjamin SeeligerJulius J SchmidtHeiko SchenkThorben PapeBernhard M W SchmidtTobias WelteMarius M HoeperAgnes SauerMalgorzata WygreckaChristian BodeHeiner WedemeyerHermann HallerSascha David

Published in: Intensive care medicine experimental (2021)

Septic shock results in profound degradation of the eGC and an acquired deficiency of the protective regulator Hpa-2. TPE removed potentially injurious eGC degradation products and partially attenuated Hpa-2 deficiency. Trial registration clinicaltrials.gov NCT04231994, retrospectively registered 18 January 2020.

Keyphrases

septic shock
replacement therapy
study protocol
endothelial cells
phase iii
clinical trial
intellectual disability
transcription factor
randomized controlled trial
autism spectrum disorder
placebo controlled