TGF-β-Induced FLRT3 Attenuation Is Essential for Cancer-Associated Fibroblast-Mediated Epithelial-Mesenchymal Transition in Colorectal Cancer.

Mengdi YangDan LiZhiyuan JiangChangcan LiSuyuan JiJing SunYujie ChangShunyi RuanZhiyu WangRui LiangXueyu DaiBin Li Hui Zhao

Published in: Molecular cancer research : MCR (2022)

CAFs enhance colorectal cancer aggressiveness by reducing FLRT3 expression through activating TGF-β/SMAD4 signaling pathway. CAF-targeted therapy and/or LY2109761 were promising treatments for colorectal cancer.

Keyphrases

epithelial mesenchymal transition
transforming growth factor
signaling pathway
pi k akt
poor prognosis
high glucose
induced apoptosis
oxidative stress
drug induced
endothelial cells