ETS2 is a prostate basal cell marker and is highly expressed in prostate cancers aberrantly expressing p63.

Alba TorresMohammed AlshalalfaElai DavicioniAnuj GuptaSrinivasan YegnasubramanianSarah J WheelanJonathan I EpsteinAngelo M De MarzoTamara L Lotan

Published in: The Prostate (2018)

ETS2 is a predominantly basally-expressed gene in the prostate, with low expression in usual-type adenocarcinoma and high expression in p63-expressing carcinomas. Given this pattern, the significance of ETS2 loss by deletion or mutation in usual-type adenocarcinomas is uncertain.

Keyphrases

prostate cancer
transcription factor
poor prognosis
benign prostatic hyperplasia
binding protein
single cell
copy number
high grade
genome wide
gene expression
mesenchymal stem cells
radiation therapy
locally advanced
african american