In contrast to other cancer research areas, the development of chemotherapy and radiotherapy for meningiomas has been challenging, lacking standardized criteria for assessing treatment response and progression. Although efforts by RANO have proposed evaluation criteria, a consensus on effective evaluation parameters for meningiomas remains elusive. This paper underscores the importance of establishing efficacy endpoints in clinical trials, compares efficacy assessment in meningioma research with other solid tumor areas, and outlines the challenges ahead in meningioma research. Recent analyses revealed the absence of consensus on efficacy endpoints in meningioma trials, complicating trial design and hindering cross-trial comparisons. The unique anatomical constraints and histological variability of meningiomas pose challenges in determining appropriate efficacy measures. To address these challenges, future research must focus on accumulating prognostic data, standardizing evaluation criteria, and considering multiple endpoints in trial designs. Akin to other cancer areas, investigating targeted therapies and establishing international consensus on efficacy endpoints are crucial steps forward.
Keyphrases
- clinical trial
- phase ii
- study protocol
- phase iii
- early stage
- magnetic resonance
- clinical practice
- radiation therapy
- randomized controlled trial
- locally advanced
- magnetic resonance imaging
- squamous cell
- optic nerve
- electronic health record
- deep learning
- current status
- contrast enhanced
- radiation induced
- data analysis
- optical coherence tomography
- lymph node metastasis