Atorvastatin Induces FXR and CYP7A1 Activation as a Result of the Sequential Action of PPARγ/PGC-1α/HNF-4α in Hep3B Cells.

Jin LeeEun Mi HongJang Han JungSe Woo ParkSang Pyo LeeDong Hee KohHyun Joo JangSea Hyub Kae

Published in: The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi (2021)

Atorvastatin induces FXR and CYP7A1 activation as a result of sequential action of PPARγ/PGC-1α/HNF-4α in human hepatocytes. We propose that atorvastatin enhances solubility of cholesterol in bile by simultaneously activating of FXR and CYP7A1.

Keyphrases

skeletal muscle
insulin resistance
endothelial cells
nuclear factor
signaling pathway
fatty acid
type diabetes
induced pluripotent stem cells
metabolic syndrome
adipose tissue
inflammatory response
liver injury