Tissue Kallikrein Protects Rat Prostate against the Inflammatory Damage in a Chronic Autoimmune Prostatitis Model via Restoring Endothelial Function in a Bradykinin Receptor B2-Dependent Way.

Mengyang Zhang Dongxu Lin Changcheng Luo Pengyu Wei Kai Cui Zhong Chen

Published in: Oxidative medicine and cellular longevity (2022)

The KLK1 expression is inhibited in the inflamed prostates of humans and rats. Exogenous KLK1 restored endothelial function via a BDKRB2-dependent way and then played a role in improving microcirculation and exerted anti-inflammatory, antifibrotic, and antioxidative stress effects in the rat chronic-inflamed prostate.

Keyphrases

oxidative stress
anti inflammatory
benign prostatic hyperplasia
prostate cancer
poor prognosis
drug induced
multiple sclerosis
binding protein
heat stress
pulmonary fibrosis