Neurobiological effects of gallic acid: current perspectives.
Md Shimul BhuiaMd Mizanur RahamanTawhida IslamMehedi Hasan BappiMd Iqbal SikderKazi Nadim HossainFatama AkterAbdullah Al Shamsh ProttayMd RokonuzzmanEda Sönmez GürerDaniela CalinaMuhammad Torequl IslamJavad Sharifi RadPublished in: Chinese medicine (2023)
Gallic acid (GA) is a phenolic molecule found naturally in a wide range of fruits as well as in medicinal plants. It has many health benefits due to its antioxidant properties. This study focused on finding out the neurobiological effects and mechanisms of GA using published data from reputed databases. For this, data were collected from various sources, such as PubMed/Medline, Science Direct, Scopus, Google Scholar, SpringerLink, and Web of Science. The findings suggest that GA can be used to manage several neurological diseases and disorders, such as Alzheimer's disease, Parkinson's disease, strokes, sedation, depression, psychosis, neuropathic pain, anxiety, and memory loss, as well as neuroinflammation. According to database reports and this current literature-based study, GA may be considered one of the potential lead compounds to treat neurological diseases and disorders. More preclinical and clinical studies are required to establish GA as a neuroprotective drug.
Keyphrases
- pet ct
- neuropathic pain
- public health
- electronic health record
- spinal cord
- cerebral ischemia
- spinal cord injury
- healthcare
- adverse drug
- systematic review
- traumatic brain injury
- depressive symptoms
- oxidative stress
- randomized controlled trial
- sleep quality
- stem cells
- working memory
- risk assessment
- cognitive decline
- anti inflammatory
- lipopolysaccharide induced
- human health
- cognitive impairment
- deep learning
- climate change
- meta analyses