Comparative Pharmacokinetics of Commercially Available Cannabidiol Isolate, Broad-Spectrum, and Full-Spectrum Products.
Erin C BertholdShyam H KambleSiva Rama Raju KanumuriMichelle A KuntzAlexandria S SenetraYi-Hua ChiangLance R McMahonChristopher R McCurdyAbhisheak SharmaPublished in: European journal of drug metabolism and pharmacokinetics (2023)
The presence of 0.2% THC increased the oral bioavailability of CBD in male and female rats, indicating that full-spectrum products may produce increased effectiveness of CBD due to a greater exposure available systemically.