Sex-dependent effects of angiotensin type 2 receptor expressing medial prefrontal cortex (mPFC) interneurons in fear extinction learning.

Hannah C Smith Zhe Yu Laxmi Iyer Paul J Marvar

Published in: bioRxiv : the preprint server for biology (2023)

These results lend support for mPFC-AT2R+ neurons as a novel subgroup of somatostatin interneurons that influence fear extinction in a sex-dependent manner. This furthers underscores the role of mPFC in top-down regulation and a unique role for peptidergic (ie., angiotensin) mPFC regulation of fear and sex differences.

Keyphrases

prefrontal cortex
angiotensin converting enzyme
angiotensin ii
clinical trial
randomized controlled trial
study protocol