Therapeutic drug monitoring of mycophenolic acid (MPA) using volumetric absorptive microsampling (VAMS) in pediatric renal transplant recipients: ultra-high-performance liquid chromatography-tandem mass spectrometry analytical method development, cross-validation, and clinical application.

Arkadiusz Kocur Jacek Rubik Paweł Czarnowski Agnieszka Czajkowska Dorota Marszałek Maciej SierakowskiMarta GórskaTomasz Pawinski

Published in: Pharmacological reports : PR (2023)

This study is the first development of a triple matrix-based LC-MS/MS method for MPA determination in the pediatric population after renal transplantation. For the first time, the developed methods were cross-validated with routinely used HPLC-DAD protocol.

Keyphrases

simultaneous determination
liquid chromatography tandem mass spectrometry
solid phase extraction
ms ms
high performance liquid chromatography
liquid chromatography
tandem mass spectrometry
molecularly imprinted
mass spectrometry
randomized controlled trial
high resolution
high resolution mass spectrometry