An optimized radiosynthesis of [ 18 F]DK222, a PET radiotracer for imaging PD-L1.
Daniel P HoltDhiraj KumarSridhar NimmagaddaRobert F DannalsPublished in: Journal of labelled compounds & radiopharmaceuticals (2023)
A radiochemical synthesis of [ 18 F]DK222, a peptide binder of programmed death ligand 1 protein, suitable for human PET studies is described, and results from validation productions are presented. The high specific activity radiotracer product is prepared as a sterile, apyrogenic solution that conforms to current Good Manufacturing Practice (cGMP) requirements. In addition, the production is extended to use a commercial synthesizer platform (General Electric FASTlab 2).
Keyphrases
- pet imaging
- positron emission tomography
- endothelial cells
- high resolution
- primary care
- nitric oxide
- healthcare
- induced pluripotent stem cells
- computed tomography
- high throughput
- pluripotent stem cells
- protein protein
- quality improvement
- binding protein
- case control
- amino acid
- protein kinase
- photodynamic therapy
- mass spectrometry
- fluorescence imaging
- single cell