Heterogeneous Patterns of Endothelial NF-κB p65 and MAPK c-Jun Activation, Adhesion Molecule Expression, and Leukocyte Recruitment in Lung Microvasculature of Mice with Sepsis.
Zhendong WangErna-Zulaikha DayangPeter J ZwiersMartha L Hernandez GarciaMatthijs LuxenMatijs van MeursJill MoserJan A A M KampsGrietje MolemaPublished in: Biomedicines (2024)
Endothelial activation and leukocyte recruitment in sepsis-induced lung injury are regulated by multiple, heterogeneously controlled mechanisms, which vary depending on the type of microvascular bed involved.
Keyphrases
- signaling pathway
- acute kidney injury
- endothelial cells
- septic shock
- intensive care unit
- high glucose
- oxidative stress
- pi k akt
- poor prognosis
- diabetic rats
- peripheral blood
- high fat diet induced
- type diabetes
- escherichia coli
- drug induced
- binding protein
- nuclear factor
- metabolic syndrome
- immune response
- cell proliferation
- cystic fibrosis
- inflammatory response
- insulin resistance