Aspirin inhibits RANKL-induced osteoclast differentiation in dendritic cells by suppressing NF-κB and NFATc1 activation.
Lili WuZhenhua LuoYitong LiuLu JiaYiyang JiangJuan DuLijia GuoYuxing BaiYi LiuPublished in: Stem cell research & therapy (2019)
Aspirin inhibited RANKL-induced OC differentiation in DCs via the NF-κB pathway, downregulating expression of NFATc1. Aspirin treatment promoted bone regeneration by inhibiting DDOC activation in the early stages of inflammation in a rat mandibular bone defect model.
Keyphrases
- bone regeneration
- oxidative stress
- low dose
- signaling pathway
- dendritic cells
- diabetic rats
- nuclear factor
- bone loss
- high glucose
- cardiovascular events
- antiplatelet therapy
- lps induced
- poor prognosis
- type diabetes
- inflammatory response
- acute coronary syndrome
- coronary artery disease
- endothelial cells
- toll like receptor
- anti inflammatory drugs
- long non coding rna
- percutaneous coronary intervention