Downregulation of interleukin 36γ and its cleaver cathepsin G following treatment with narrow-band ultraviolet B phototherapy in psoriasis vulgaris.

Mona El-Kalioby Mohamed Hussein Medhat El-Komy Eman Raafat SaidMarwa Ahmed AmerDina G SaadiFaisal Nouredin MohammedLaila Ahmed RashedEman D El DesoukyAya M AlOrbani

Published in: The Journal of dermatological treatment (2021)

IL-36γ and cathepsin G expression is upregulated in psoriatic lesions, supporting their role as mediators of inflammation in psoriasis. Downregulation of IL-36γ and cathepsin G is a possible mechanism for psoriasis improvement after NB-UVB therapy. IL-36 and cathepsin G can be considered as therapeutic targets for psoriasis.

Keyphrases

cell proliferation
atopic dermatitis
signaling pathway
poor prognosis
oxidative stress
stem cells
ankylosing spondylitis
mesenchymal stem cells
binding protein
combination therapy
systemic lupus erythematosus
chemotherapy induced
bone marrow
smoking cessation