Systematic review and meta-analysis of the moderating effect of rs1799971 in OPRM1, the mu-opioid receptor gene, on response to naltrexone treatment of alcohol use disorder.

Emily E HartwellRichard FeinnPaige E MorrisJoel GelernterJohn KrystalAlbert J AriasMichaela HoffmanIsmene PetrakisRalitza GueorguievaJoseph P SchachtDavid OslinRaymond F AntonHenry R Kranzler

Published in: Addiction (Abingdon, England) (2020)

From the evidence to date, it remains unclear whether rs1799971, the OPRM1 Asn40Asp single nucleotide polymorphism, predicts naltrexone treatment response in individuals with alcohol use disorder or heavy drinking.

Keyphrases

alcohol use disorder
chronic pain
pain management
copy number
genome wide
social support
gene expression
combination therapy
dna methylation
alcohol consumption
transcription factor