Cancer-specific tissue-resident memory T-cells express ZNF683 in colorectal cancer.
Masatoshi KitakazeMamoru UemuraTomoaki HaraRyota ChijimatsuDaisuke MotookaToshiro HiraiMasamitsu KonnoDaisuke OkuzakiYuki SekidoTsuyoshi HataTakayuki OginoHidekazu TakahashiNorikatsu MiyoshiKen OfusaTsunekazu MizushimaHidetoshi EguchiYuichiro DokiHideshi IshiiPublished in: British journal of cancer (2023)
TILs is a prognostic predictive factor in CRC. In addition, we identified the ZNF683 expression as one of the candidate markers of cancer-specific Trm cells. IFN-γ and TCR signalling and ZNF683 expression are involved in Trm cell activation in tumours and are promising targets for cancer immunity regulation.
Keyphrases
- papillary thyroid
- poor prognosis
- squamous cell
- induced apoptosis
- lymph node metastasis
- immune response
- dendritic cells
- squamous cell carcinoma
- single cell
- working memory
- oxidative stress
- signaling pathway
- patient safety
- cell cycle arrest
- long non coding rna
- cell therapy
- mesenchymal stem cells
- endoplasmic reticulum stress