Motor cortex transcriptome reveals microglial key events in amyotrophic lateral sclerosis.
Oriol Dols-IcardoVíctor MontalSònia SirisiGema López-PernasLaura Cervera-CarlesMarta Querol-VilasecaLaia MuñozOlivia BelbinDaniel AlcoleaLaura Molina-PorcelJordi PeguerolesJanina Turón-SansRafael BlesaAlberto LleóJuan ForteaRicard Rojas-GarcíaJordi ClarimónPublished in: Neurology(R) neuroimmunology & neuroinflammation (2020)
DAM has a central role in microglia-related neuroinflammatory changes in the motor cortex of patients with ALS, and these alterations are coupled with a reduced expression of postsynaptic transcripts.