Motor cortex transcriptome reveals microglial key events in amyotrophic lateral sclerosis.

Oriol Dols-IcardoVíctor MontalSònia SirisiGema López-PernasLaura Cervera-Carles Marta Querol-VilasecaLaia MuñozOlivia Belbin Daniel Alcolea Laura Molina-Porcel Jordi PeguerolesJanina Turón-SansRafael BlesaAlberto LleóJuan ForteaRicard Rojas-GarcíaJordi Clarimón

Published in: Neurology(R) neuroimmunology & neuroinflammation (2020)

DAM has a central role in microglia-related neuroinflammatory changes in the motor cortex of patients with ALS, and these alterations are coupled with a reduced expression of postsynaptic transcripts.

Keyphrases

inflammatory response
neuropathic pain
poor prognosis
lipopolysaccharide induced
rna seq
gene expression
single cell
lps induced
genome wide
amyotrophic lateral sclerosis
binding protein
spinal cord injury
long non coding rna
spinal cord
drug induced