Novel artificial nerve transplantation of human iPSC-derived neurite bundles enhanced nerve regeneration after peripheral nerve injury.
Takayuki NishijimaKentaro OkuyamaShinsuke ShibataHiroo KimuraMunehisa ShinozakiTakehito OuchiYo MabuchiTatsukuni OhnoJunpei NakayamaManabu HayatsuKeiko UchiyamaTomoko ShindoEri NiiyamaSayaka ToitaJiro KawadaTakuji IwamotoMasaya NakamuraHideyuki OkanoNarihito NagoshiPublished in: Inflammation and regeneration (2024)
The combination of newly developed microfluidic devices and iPSC technology enables the preparation of artificial nerves from organoid-derived neurite bundles in advance for future treatment of peripheral nerve injury patients. A promising, safe, and effective peripheral nerve treatment is now ready for clinical application.