Corneal and conjunctival alteration of innate immune expression in first-degree relatives of keratoconus patients.

Uxía RegueiroMaite López-LópezPablo Hervella Tomás Sobrino Isabel Lema

Published in: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (2020)

TLR2 and TLR4 are overexpressed in corneal and conjunctival epithelial cells of KC relatives compared with controls. Both biomarkers may monitor early ocular changes in first-degree relatives who not show any abnormal clinical-topographic-aberrometric-tomographic parameters.

Keyphrases

innate immune
end stage renal disease
toll like receptor
inflammatory response
immune response
newly diagnosed
ejection fraction
chronic kidney disease
poor prognosis
optical coherence tomography
peritoneal dialysis
wound healing
prognostic factors
patient reported outcomes
nuclear factor
binding protein