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Synthesis of Novel Diphenyl Ether-Based Bis-Heterocycles as Novel Hybrid Molecules via Michael and Other Cyclocondensation Reactions.

Mostafa E SalemYassmen A El-GabryIsmail A AbdelhamidAhmed H M ElwahyMagdi E A ZakiHadeer M Diab
Published in: ACS omega (2024)
Molecular hybridization is a technique used in drug creation that involves combining the pharmacophoric moieties of multiple bioactive compounds to create a new hybrid molecule with better affinity and effectiveness. In this regard, we created unique hybrid molecules out of diphenyl ether-linked fused pyrans and other heterocycles. The Michael reaction of 4,4'-oxydibenzaldehyde with malononitrile and various active methylene derivatives, as well as enaminone derivatives, produced the matching bis-fused pyrans and fused pyridines, both connected to a diphenyl ether moiety. Furthermore, the acid-catalyzed reaction of 4,4'-oxydibenzaldehyde with dimedone or β-naphthol produced the corresponding new bis(hexahydro-1 H -xanthene-1,8-dione) and bis(14 H -dibenzo[ a , j ]xanthene). The processes by which the target products are formed were also examined.
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