Protein therapy of skeletal muscle atrophy and mechanism by angiogenic factor AGGF1.
Zuhan HeQixue SongYubing YuFeng LiuJinyan ZhaoWaikeong UnXingwen DaChengqi XuYufeng YaoQing Kenneth WangPublished in: Journal of cachexia, sarcopenia and muscle (2023)
These results indicate that AGGF1 is a novel regulator for the pathogenesis of skeletal muscle atrophy and attenuates skeletal muscle atrophy by promoting autophagy and inhibiting MuRF1 expression through a molecular signalling pathway of AGGF1-TWEAK/Fn14-NF-κB. More importantly, the results indicate that AGGF1 protein therapy may be a novel approach to treat patients with skeletal muscle atrophy.
Keyphrases
- skeletal muscle
- insulin resistance
- signaling pathway
- oxidative stress
- poor prognosis
- binding protein
- cell death
- protein protein
- metabolic syndrome
- lps induced
- endoplasmic reticulum stress
- transcription factor
- type diabetes
- pi k akt
- immune response
- single molecule
- cell proliferation
- long non coding rna
- small molecule
- bone marrow
- nuclear factor
- toll like receptor