Glycogen Synthase Kinase-3 Isoform Variants and Their Inhibitory Phosphorylation in Human Testes and Spermatozoa.
Seung Hyun ParkYang XuYong Seog ParkJu Tae SeoMyung Chan GyePublished in: The world journal of men's health (2022)
In human male germ cells, GSK3 isoforms different in LCRs switch from GSK3β to GSK3α during meiotic entry, suggesting the isoform-specific roles of GSK3α and GSK3β in meiosis and stemness or proliferation of spermatogonia, respectively. In dormant Sertoli cells of SCO testes kinase activity of GSK3 might be downregulated via inhibitory phosphorylation. In spermatozoa, inhibitory phosphorylation of GSK3α might be coupled with activation of motility during capacitation.
Keyphrases
- signaling pathway
- pi k akt
- induced apoptosis
- cell cycle arrest
- protein kinase
- endothelial cells
- epithelial mesenchymal transition
- stem cells
- induced pluripotent stem cells
- gene expression
- staphylococcus aureus
- tyrosine kinase
- cell death
- endoplasmic reticulum stress
- dna methylation
- pluripotent stem cells
- genome wide