Correlations between pathogenic variants in DNA repair genes and anticancer treatment efficacy in stage IV non-small cell lung cancer: A large real-world cohort and review of the literature.
Itamar AverbuchRoi TschernichovskyOded IchtDaniel A GoldsteinRaz MutaiElizabeth DudnikOfer RotemNir PeledAaron M AllenSmadar Laufer-GevaYael GoldbergAlona ZerPublished in: Thoracic cancer (2023)
Our retrospective data suggest that in patients with stage 4 NSCLC, pathogenic variants in DDR pathway genes may be associated with higher efficacy of radiotherapy and immune checkpoint inhibitors (ICIs). This should be further explored prospectively.
Keyphrases
- dna repair
- dna damage
- copy number
- genome wide
- small cell lung cancer
- early stage
- bioinformatics analysis
- genome wide identification
- dna damage response
- cross sectional
- radiation therapy
- electronic health record
- big data
- squamous cell carcinoma
- locally advanced
- oxidative stress
- rectal cancer
- deep learning
- data analysis