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Population homogeneity for the antibody response to COVID-19 BNT162b2/Comirnaty vaccine is only reached after the second dose across all adult age ranges.

João Faro VianaMarie-Louise BergmanLígia A GonçalvesNádia DuarteTeresa P CoutinhoPatrícia C BorgesChristian DiwoRute CastroPaula MatosoVanessa MalheiroAna BrennandLindsay KosackOnome AkpoghenetaJoão M FigueiraConceição CardosoAna M CasacaPaula M AlvesTelmo NunesCarlos P GonçalvesJocelyne Demengeot
Published in: Nature communications (2022)
While mRNA vaccines are administrated worldwide in an effort to contain the COVID-19 pandemic, the heterogeneity of the humoral immune response they induce at the population scale remains unclear. Here, in a prospective, longitudinal, cohort-study, including 1245 hospital care workers and 146 nursing home residents scheduled for BNT162b2 vaccination, together covering adult ages from 19 to 99 years, we analyse seroconversion to SARS-CoV-2 spike protein and amount of spike-specific IgG, IgM and IgA before vaccination, and 3-5 weeks after each dose. We show that immunogenicity after a single vaccine dose is biased to IgG, heterogeneous and reduced with increasing age. The second vaccine dose normalizes IgG seroconversion in all age strata. These findings indicate two dose mRNA vaccines is required to reach population scale humoral immunity. The results advocate for the interval between the two doses not to be extended, and for serological monitoring of elderly and immunosuppressed vaccinees.
Keyphrases
  • immune response
  • sars cov
  • healthcare
  • coronavirus disease
  • emergency department
  • dendritic cells
  • cross sectional
  • middle aged
  • chronic pain
  • health insurance