Colorectal cancer-specific IFNβ delivery overcomes dysfunctional dsRNA-mediated type I interferon signaling to increase the abscopal effect of radiotherapy.
Kevin Chih-Yang HuangShu-Fen ChiangHsin-Yu ChangWei-Ze HongJhen-Yu ChenPei-Chih LeeJi-An LiangTao-Wei KeShin-Lei PengAn-Cheng ShiauTsung-Wei ChenPei-Chen YangWilliam Tzu-Liang ChenKun-San Clifford ChaoPublished in: Journal for immunotherapy of cancer (2024)
Our results support that increasing cancer-intrinsic IFNβ1 expression is an immunotherapeutic strategy that enhances the RT-induced antitumor immune response in locally patients with advanced CRC with dysfunctional TLR3.
Keyphrases
- immune response
- dendritic cells
- toll like receptor
- papillary thyroid
- poor prognosis
- high glucose
- early stage
- diabetic rats
- squamous cell
- radiation therapy
- locally advanced
- radiation induced
- binding protein
- inflammatory response
- endothelial cells
- squamous cell carcinoma
- lymph node metastasis
- long non coding rna
- drug induced
- young adults