A Comparison of Human and Porcine Skin in Laser-Assisted Drug Delivery of Chemotherapeutics.

Lukas Kristian Rosenberg Charlotte Bagger Christian Janfelt Merete Haedersdal Uffe Hoegh Olesen Catharina Margrethe Lerche

Published in: Lasers in surgery and medicine (2020)

Normal porcine and human skin showed similar morphology, the composition of endogenous lipids, and AFL-assisted cutaneous uptake, and biodistribution of chemotherapeutics. Therefore, normal porcine skin, but not hyperkeratotic pig phenotype skin, is a practical and reliable model for healthy human skin in ex vivo LADD diffusion studies. Lasers Surg. Med. © 2020 Wiley Periodicals LLC.

Keyphrases

soft tissue
drug delivery
wound healing
endothelial cells
cancer therapy
computed tomography
fatty acid
high speed
case control
drug release