Acute myeloid leukemia with inv(16)(p13.1q22) and deletion of the 5'MYH11/3'CBFB gene fusion: a report of two cases and literature review.
Lili LvJingwei YuZhongxia QiPublished in: Molecular cytogenetics (2020)
Deletion of 3'CBFB in AML with inv(16) is also accompanied with deletion of 5'MYH11 in all the cases studied by SNP microarray, suggesting that 3'CBFB and 5'MYH11 were most likely deleted together as a fusion product of inv(16) instead of occurring separately. In concert with the findings of other published studies of similar patients, our study suggests that deletion of 5'MYH11/3'CBFB in AML with inv(16) may not have negative impact on the prognosis of the disease.
Keyphrases
- acute myeloid leukemia
- hypertrophic cardiomyopathy
- end stage renal disease
- allogeneic hematopoietic stem cell transplantation
- genome wide
- ejection fraction
- newly diagnosed
- left ventricular
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- randomized controlled trial
- systematic review
- gene expression
- transcription factor
- patient reported
- high density