Applying a genetic risk score for prostate cancer to men with lower urinary tract symptoms in primary care to predict prostate cancer diagnosis: a cohort study in the UK Biobank.

Harry D GreenSamuel W D MerrielRichard A OramKatherine S RuthJessica TyrrellSamuel E JonesChrissie ThirlwellMichael N WeedonSarah Elizabeth Rose Bailey

Published in: British journal of cancer (2022)

This study is the first to apply GRS in primary care to improve the triage of symptomatic patients. Men with the lowest genetic risk of developing prostate cancer could safely avoid invasive investigation, whilst those identified with the greatest risk could be fast-tracked for further investigation. These results show that a GRS has potential application to improve the diagnostic pathway of symptomatic patients in primary care.

Keyphrases

prostate cancer
primary care
end stage renal disease
radical prostatectomy
chronic kidney disease
ejection fraction
newly diagnosed
lower urinary tract symptoms
prognostic factors
emergency department
patient reported outcomes
gene expression
benign prostatic hyperplasia
patient reported
cross sectional