The Common H202D Variant in GDF-15 Does Not Affect Its Bioactivity but Can Significantly Interfere with Measurement of Its Circulating Levels.
Yanislava KarushevaMatthew RatcliffAlexander MörseburgPeter BarkerAudrey MelvinNaveed SattarKeith BurlingAnna BackmarkRobert RothLutz JermutusEsther Guiu-JuradoMatthias BlüherPaul I WelshMarko HyvönenStephen I O'RahillyPublished in: The journal of applied laboratory medicine (2022)
The D variant of GDF-15 substantially affects its measurement by a commonly used immunoassay, a finding that has clear implications for its interpretation in research and clinical settings.
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