Stephen I O'Rahilly (Stephen O'Rahilly, S O'Rahilly)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 65

Top Venues

eLife

Scientific reports

Nature genetics

Proceedings of the National Academy of Sciences of the United States of America

University of Cambridge

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Cambridge

United Kingdom

Co-Director :: WT-MRC Institute of Metabolic Science

University of Cambridge

United Kingdom

Director :: MRC Metabolic Diseases Unit

Addenbrooke's Hospital Jan 01 2011

United Kingdom

Scientific Director :: Cambridge Biomedical Research Centre

University of Cambridge

United Kingdom

Director :: Metabolic Research Laboratories

University of Cambridge Oct 01 2002

United Kingdom

Professor of Clinical Biochemistry and Medicine :: Department of Clinical Biochemistry

University of Cambridge

United Kingdom

Head of Department :: Clinical Biochemistry

Addenbrooke's Hospital Jan 01 1994

United Kingdom

Honorary Consultant Physician :: Diabetes and Endocrinology

Publications

John W R Kincaid, Debra Rimmington, John A Tadross, Irene Cimino, Ilona Zvetkova, Arthur Kaser, Paul Richards, Satish Patel, Stephen I O'Rahilly, Anthony P Coll
The gastrointestinal tract is a major source of the acute metformin-stimulated rise in GDF15. Scientific reports 14 (1) (2024)
Yajie Zhao, Maria Chukanova, Katherine A Kentistou, Zammy Fairhurst-Hunter, Anna Maria Siegert, Raina Y Jia, Georgina K C Dowsett, Eugene J Gardner, Katherine L Lawler, Felix R Day, Lena R Kaisinger, Yi-Chun Loraine Tung, Brian Yee Hong Lam, Hsiao-Jou Cortina Chen, Quanli Wang, Jaime Berumen-Campos, Pablo Kuri-Morales, Roberto Tapia-Conyer, Jesus Alegre, Inês A Barroso, Jonathan R Emberson, Jason M Torres, Rory Collins, Danish Saleheen, Katherine R Smith, Dirk S Paul, Florian T Merkle, I Sadaf Farooqi, Nicholas J Wareham, Slavé Petrovski, Stephen I O'Rahilly, Ken K Ong, Giles S H Yeo, John R B Perry
Protein-truncating variants in BSN are associated with severe adult-onset obesity, type 2 diabetes and fatty liver disease. Nature genetics 56 (4) (2024)
Katherine A Kentistou, Brandon E M Lim, Lena R Kaisinger, Valgerdur Steinthorsdottir, Luke N Sharp, Kashyap Amratlal Patel, Vinicius Tragante, Gareth Hawkes, Eugene J Gardner, Thorhildur Olafsdottir, Andrew R Wood, Yajie Zhao, Gudmar Thorleifsson, Felix R Day, Susan E Ozanne, Andrew T Hattersley, Stephen I O'Rahilly, Kari Stefansson, Ken K Ong, Robin N Beaumont, John R B Perry, Rachel M Freathy
Rare variant associations with birth weight identify genes involved in adipose tissue regulation, placental function and insulin-like growth factor signalling. medRxiv : the preprint server for health sciences (2024)
Marie T Dittmann, Gabriella Lakatos, Jodie F Wainwright, Jacek Mokrosinski, Eloise Cross, I Sadaf Farooqi, Natalie J Wallis, Lewis G Halsey, Rory P Wilson, Stephen I O'Rahilly, Giles S H Yeo, Eleanor Raffan
Low resting metabolic rate and increased hunger due to β-MSH and β-endorphin deletion in a canine model. Science advances 10 (10) (2024)
Yajie Zhao, Maria Chukanova, Katherine A Kentistou, Zammy Fairhurst-Hunter, Anna Maria Siegert, Raina Y Jia, Georgina K C Dowsett, Eugene J Gardner, Katherine L Lawler, Felix R Day, Lena R Kaisinger, Yi-Chun Loraine Tung, Brian Yee Hong Lam, Hsiao-Jou Cortina Chen, Quanli Wang, Jaime Berumen-Campos, Pablo Kuri-Morales, Roberto Tapia-Conyer, Jesus Alegre, Inês A Barroso, Jonathan R Emberson, Jason M Torres, Rory Collins, Danish Saleheen, Katherine R Smith, Dirk S Paul, Florian T Merkle, I Sadaf Farooqi, Nicholas J Wareham, Slavé Petrovski, Stephen I O'Rahilly, Ken K Ong, Giles S H Yeo, John R B Perry
Protein-truncating variants in BSN are associated with severe adult-onset obesity, type 2 diabetes and fatty liver disease. Nature genetics 56 (4) (2024)
Jérémie Gautheron, Solaf Elsayed, Valeria Pistorio, Sam Lockhart, Jamila Zammouri, Martine Auclair, Albert Koulman, Sarah R Meadows, Marie Lhomme, Maharajah Ponnaiah, Redouane Si-Bouazza, Sylvie Fabrega, Abdelaziz Belkadi, null null, Jean-Louis Delaunay, Tounsia Aït-Slimane, Bruno Fève, Corinne Vigouroux, Tawhida Y Abdel Ghaffar, Stephen I O'Rahilly, Isabelle Jéru
ADH1B, the adipocyte-enriched alcohol dehydrogenase, plays an essential, cell-autonomous role in human adipogenesis. Proceedings of the National Academy of Sciences of the United States of America 121 (24) (2024)
Yajie Zhao, Maria Chukanova, Katherine A Kentistou, Zammy Fairhurst-Hunter, Anna Maria Siegert, Raina Y Jia, Georgina K C Dowsett, Eugene J Gardner, Katherine L Lawler, Felix R Day, Lena R Kaisinger, Yi-Chun Loraine Tung, Brian Yee Hong Lam, Hsiao-Jou Cortina Chen, Quanli Wang, Jaime Berumen-Campos, Pablo Kuri-Morales, Roberto Tapia-Conyer, Jesus Alegre, Inês A Barroso, Jonathan R Emberson, Jason M Torres, Rory Collins, Danish Saleheen, Katherine R Smith, Dirk S Paul, Florian T Merkle, I Sadaf Farooqi, Nicholas J Wareham, Slavé Petrovski, Stephen I O'Rahilly, Ken K Ong, Giles S H Yeo, John R B Perry
Protein-truncating variants in BSN are associated with severe adult-onset obesity, type 2 diabetes and fatty liver disease. Nature genetics (2024)
John W R Kincaid, Debra Rimmington, John A Tadross, Irene Cimino, Ilona Zvetkova, Arthur Kaser, Paul Richards, Satish Patel, Stephen I O'Rahilly, Anthony P Coll
The gastrointestinal tract is a major source of the acute metformin-stimulated rise in GDF15. Scientific reports 14 (1) (2024)
Yajie Zhao, Maria Chukanova, Katherine A Kentistou, Zammy Fairhurst-Hunter, Anna Maria Siegert, Raina Y Jia, Georgina K C Dowsett, Eugene J Gardner, Katherine L Lawler, Felix R Day, Lena R Kaisinger, Yi-Chun Loraine Tung, Brian Yee Hong Lam, Hsiao-Jou Cortina Chen, Quanli Wang, Jaime Berumen-Campos, Pablo Kuri-Morales, Roberto Tapia-Conyer, Jesus Alegre, Inês A Barroso, Jonathan R Emberson, Jason M Torres, Rory Collins, Danish Saleheen, Katherine R Smith, Dirk S Paul, Florian T Merkle, I Sadaf Farooqi, Nicholas J Wareham, Slavé Petrovski, Stephen I O'Rahilly, Ken K Ong, Giles S H Yeo, John R B Perry
Protein-truncating variants in BSN are associated with severe adult-onset obesity, type 2 diabetes and fatty liver disease. Nature genetics 56 (4) (2024)
Jérémie Gautheron, Solaf Elsayed, Valeria Pistorio, Sam Lockhart, Jamila Zammouri, Martine Auclair, Albert Koulman, Sarah R Meadows, Marie Lhomme, Maharajah Ponnaiah, Redouane Si-Bouazza, Sylvie Fabrega, Abdelaziz Belkadi, null null, Jean-Louis Delaunay, Tounsia Aït-Slimane, Bruno Fève, Corinne Vigouroux, Tawhida Y Abdel Ghaffar, Stephen I O'Rahilly, Isabelle Jéru
ADH1B, the adipocyte-enriched alcohol dehydrogenase, plays an essential, cell-autonomous role in human adipogenesis. Proceedings of the National Academy of Sciences of the United States of America 121 (24) (2024)
Katherine A Kentistou, Brandon E M Lim, Lena R Kaisinger, Valgerdur Steinthorsdottir, Luke N Sharp, Kashyap Amratlal Patel, Vinicius Tragante, Gareth Hawkes, Eugene J Gardner, Thorhildur Olafsdottir, Andrew R Wood, Yajie Zhao, Gudmar Thorleifsson, Felix R Day, Susan E Ozanne, Andrew T Hattersley, Stephen I O'Rahilly, Kari Stefansson, Ken K Ong, Robin N Beaumont, John R B Perry, Rachel M Freathy
Rare variant associations with birth weight identify genes involved in adipose tissue regulation, placental function and insulin-like growth factor signalling. medRxiv : the preprint server for health sciences (2024)
Marie T Dittmann, Gabriella Lakatos, Jodie F Wainwright, Jacek Mokrosinski, Eloise Cross, I Sadaf Farooqi, Natalie J Wallis, Lewis G Halsey, Rory P Wilson, Stephen I O'Rahilly, Giles S H Yeo, Eleanor Raffan
Low resting metabolic rate and increased hunger due to β-MSH and β-endorphin deletion in a canine model. Science advances 10 (10) (2024)
Maik Pietzner, Burulça Uluvar, Kristoffer J Kolnes, Per Bendix Jeppesen, S Victoria Frivold, Øyvind Skattebo, Egil I Johansen, Bjørn S Skålhegg, Jørgen F P Wojtaszewski, Anders J Kolnes, Giles S H Yeo, Stephen I O'Rahilly, Jørgen Jensen, Claudia Langenberg
Systemic proteome adaptions to 7-day complete caloric restriction in humans. Nature metabolism (2024)
Jérémie Gautheron, Solaf Elsayed, Valeria Pistorio, Sam Lockhart, Jamila Zammouri, Martine Auclair, Albert Koulman, Sarah R Meadows, Marie Lhomme, Maharajah Ponnaiah, Redouane Si-Bouazza, Sylvie Fabrega, Abdelaziz Belkadi, null null, Jean-Louis Delaunay, Tounsia Aït-Slimane, Bruno Fève, Corinne Vigouroux, Tawhida Y Abdel Ghaffar, Stephen I O'Rahilly, Isabelle Jéru
ADH1B, the adipocyte-enriched alcohol dehydrogenase, plays an essential, cell-autonomous role in human adipogenesis. Proceedings of the National Academy of Sciences of the United States of America 121 (24) (2024)
John W R Kincaid, Debra Rimmington, John A Tadross, Irene Cimino, Ilona Zvetkova, Arthur Kaser, Paul Richards, Satish Patel, Stephen I O'Rahilly, Anthony P Coll
The gastrointestinal tract is a major source of the acute metformin-stimulated rise in GDF15. Scientific reports 14 (1) (2024)
Maik Pietzner, Burulça Uluvar, Kristoffer J Kolnes, Per Bendix Jeppesen, S Victoria Frivold, Øyvind Skattebo, Egil I Johansen, Bjørn S Skålhegg, Jørgen F P Wojtaszewski, Anders J Kolnes, Giles S H Yeo, Stephen I O'Rahilly, Jørgen Jensen, Claudia Langenberg
Systemic proteome adaptions to 7-day complete caloric restriction in humans. Nature metabolism 6 (4) (2024)
Yajie Zhao, Maria Chukanova, Katherine A Kentistou, Zammy Fairhurst-Hunter, Anna Maria Siegert, Raina Y Jia, Georgina K C Dowsett, Eugene J Gardner, Katherine L Lawler, Felix R Day, Lena R Kaisinger, Yi-Chun Loraine Tung, Brian Yee Hong Lam, Hsiao-Jou Cortina Chen, Quanli Wang, Jaime Berumen-Campos, Pablo Kuri-Morales, Roberto Tapia-Conyer, Jesus Alegre, Inês A Barroso, Jonathan R Emberson, Jason M Torres, Rory Collins, Danish Saleheen, Katherine R Smith, Dirk S Paul, Florian T Merkle, I Sadaf Farooqi, Nicholas J Wareham, Slavé Petrovski, Stephen I O'Rahilly, Ken K Ong, Giles S H Yeo, John R B Perry
Protein-truncating variants in BSN are associated with severe adult-onset obesity, type 2 diabetes and fatty liver disease. Nature genetics 56 (4) (2024)
John W R Kincaid, Debra Rimmington, John A Tadross, Irene Cimino, Ilona Zvetkova, Arthur Kaser, Paul Richards, Satish Patel, Stephen I O'Rahilly, Anthony P Coll
The gastrointestinal tract is a major source of the acute metformin-stimulated rise in GDF15. Scientific reports 14 (1) (2024)
Maik Pietzner, Burulça Uluvar, Kristoffer J Kolnes, Per Bendix Jeppesen, S Victoria Frivold, Øyvind Skattebo, Egil I Johansen, Bjørn S Skålhegg, Jørgen F P Wojtaszewski, Anders J Kolnes, Giles S H Yeo, Stephen I O'Rahilly, Jørgen Jensen, Claudia Langenberg
Systemic proteome adaptions to 7-day complete caloric restriction in humans. Nature metabolism 6 (4) (2024)
John W R Kincaid, Debra Rimmington, John A Tadross, Irene Cimino, Ilona Zvetkova, Arthur Kaser, Paul Richards, Satish Patel, Stephen I O'Rahilly, Anthony P Coll
The gastrointestinal tract is a major source of the acute metformin-stimulated rise in GDF15. Scientific reports 14 (1) (2024)
Jérémie Gautheron, Solaf Elsayed, Valeria Pistorio, Sam Lockhart, Jamila Zammouri, Martine Auclair, Albert Koulman, Sarah R Meadows, Marie Lhomme, Maharajah Ponnaiah, Redouane Si-Bouazza, Sylvie Fabrega, Abdelaziz Belkadi, null null, Jean-Louis Delaunay, Tounsia Aït-Slimane, Bruno Fève, Corinne Vigouroux, Tawhida Y Abdel Ghaffar, Stephen I O'Rahilly, Isabelle Jéru
ADH1B, the adipocyte-enriched alcohol dehydrogenase, plays an essential, cell-autonomous role in human adipogenesis. Proceedings of the National Academy of Sciences of the United States of America 121 (24) (2024)
Yajie Zhao, Maria Chukanova, Katherine A Kentistou, Zammy Fairhurst-Hunter, Anna Maria Siegert, Raina Y Jia, Georgina K C Dowsett, Eugene J Gardner, Katherine L Lawler, Felix R Day, Lena R Kaisinger, Yi-Chun Loraine Tung, Brian Yee Hong Lam, Hsiao-Jou Cortina Chen, Quanli Wang, Jaime Berumen-Campos, Pablo Kuri-Morales, Roberto Tapia-Conyer, Jesus Alegre, Inês A Barroso, Jonathan R Emberson, Jason M Torres, Rory Collins, Danish Saleheen, Katherine R Smith, Dirk S Paul, Florian T Merkle, I Sadaf Farooqi, Nicholas J Wareham, Slavé Petrovski, Stephen I O'Rahilly, Ken K Ong, Giles S H Yeo, John R B Perry
Protein-truncating variants in BSN are associated with severe adult-onset obesity, type 2 diabetes and fatty liver disease. Nature genetics 56 (4) (2024)
Jérémie Gautheron, Solaf Elsayed, Valeria Pistorio, Sam Lockhart, Jamila Zammouri, Martine Auclair, Albert Koulman, Sarah R Meadows, Marie Lhomme, Maharajah Ponnaiah, Redouane Si-Bouazza, Sylvie Fabrega, Abdelaziz Belkadi, null null, Jean-Louis Delaunay, Tounsia Aït-Slimane, Bruno Fève, Corinne Vigouroux, Tawhida Y Abdel Ghaffar, Stephen I O'Rahilly, Isabelle Jéru
ADH1B, the adipocyte-enriched alcohol dehydrogenase, plays an essential, cell-autonomous role in human adipogenesis. Proceedings of the National Academy of Sciences of the United States of America 121 (24) (2024)
Katherine A Kentistou, Brandon E M Lim, Lena R Kaisinger, Valgerdur Steinthorsdottir, Luke N Sharp, Kashyap Amratlal Patel, Vinicius Tragante, Gareth Hawkes, Eugene J Gardner, Thorhildur Olafsdottir, Andrew R Wood, Yajie Zhao, Gudmar Thorleifsson, Felix R Day, Susan E Ozanne, Andrew T Hattersley, Stephen I O'Rahilly, Kari Stefansson, Ken K Ong, Robin N Beaumont, John R B Perry, Rachel M Freathy
Rare variant associations with birth weight identify genes involved in adipose tissue regulation, placental function and insulin-like growth factor signalling. medRxiv : the preprint server for health sciences (2024)
John W R Kincaid, Debra Rimmington, John A Tadross, Irene Cimino, Ilona Zvetkova, Arthur Kaser, Paul Richards, Satish Patel, Stephen I O'Rahilly, Anthony P Coll
The gastrointestinal tract is a major source of the acute metformin-stimulated rise in GDF15. Scientific reports 14 (1) (2024)
Yajie Zhao, Maria Chukanova, Katherine A Kentistou, Zammy Fairhurst-Hunter, Anna Maria Siegert, Raina Y Jia, Georgina K C Dowsett, Eugene J Gardner, Katherine L Lawler, Felix R Day, Lena R Kaisinger, Yi-Chun Loraine Tung, Brian Yee Hong Lam, Hsiao-Jou Cortina Chen, Quanli Wang, Jaime Berumen-Campos, Pablo Kuri-Morales, Roberto Tapia-Conyer, Jesus Alegre, Inês A Barroso, Jonathan R Emberson, Jason M Torres, Rory Collins, Danish Saleheen, Katherine R Smith, Dirk S Paul, Florian T Merkle, I Sadaf Farooqi, Nicholas J Wareham, Slavé Petrovski, Stephen I O'Rahilly, Ken K Ong, Giles S H Yeo, John R B Perry
Protein-truncating variants in BSN are associated with severe adult-onset obesity, type 2 diabetes and fatty liver disease. Nature genetics 56 (4) (2024)
John W R Kincaid, Debra Rimmington, John A Tadross, Irene Cimino, Ilona Zvetkova, Arthur Kaser, Paul Richards, Satish Patel, Stephen I O'Rahilly, Anthony P Coll
The gastrointestinal tract is a major source of the acute metformin-stimulated rise in GDF15. Scientific reports 14 (1) (2024)
Marie T Dittmann, Gabriella Lakatos, Jodie F Wainwright, Jacek Mokrosinski, Eloise Cross, I Sadaf Farooqi, Natalie J Wallis, Lewis G Halsey, Rory P Wilson, Stephen I O'Rahilly, Giles S H Yeo, Eleanor Raffan
Low resting metabolic rate and increased hunger due to β-MSH and β-endorphin deletion in a canine model. Science advances 10 (10) (2024)
Marie T Dittmann, Gabriella Lakatos, Jodie F Wainwright, Jacek Mokrosinski, Eloise Cross, I Sadaf Farooqi, Natalie J Wallis, Lewis G Halsey, Rory P Wilson, Stephen I O'Rahilly, Giles S H Yeo, Eleanor Raffan
Low resting metabolic rate and increased hunger due to β-MSH and β-endorphin deletion in a canine model. Science advances 10 (10) (2024)
Marie T Dittmann, Gabriella Lakatos, Jodie F Wainwright, Jacek Mokrosinski, Eloise Cross, I Sadaf Farooqi, Natalie J Wallis, Lewis G Halsey, Rory P Wilson, Stephen I O'Rahilly, Giles S H Yeo, Eleanor Raffan
Low resting metabolic rate and increased hunger due to β-MSH and β-endorphin deletion in a canine model. Science advances 10 (10) (2024)
Yajie Zhao, Maria Chukanova, Katherine A Kentistou, Zammy Fairhurst-Hunter, Anna Maria Siegert, Raina Y Jia, Georgina K C Dowsett, Eugene J Gardner, Katherine L Lawler, Felix R Day, Lena R Kaisinger, Yi-Chun Loraine Tung, Brian Yee Hong Lam, Hsiao-Jou Cortina Chen, Quanli Wang, Jaime Berumen-Campos, Pablo Kuri-Morales, Roberto Tapia-Conyer, Jesus Alegre, Inês A Barroso, Jonathan R Emberson, Jason M Torres, Rory Collins, Danish Saleheen, Katherine R Smith, Dirk S Paul, Florian T Merkle, I Sadaf Farooqi, Nicholas J Wareham, Slavé Petrovski, Stephen I O'Rahilly, Ken K Ong, Giles S H Yeo, John R B Perry
Protein-truncating variants in BSN are associated with severe adult-onset obesity, type 2 diabetes and fatty liver disease. Nature genetics 56 (4) (2024)
Maik Pietzner, Burulça Uluvar, Kristoffer J Kolnes, Per Bendix Jeppesen, S Victoria Frivold, Øyvind Skattebo, Egil I Johansen, Bjørn S Skålhegg, Jørgen F P Wojtaszewski, Anders J Kolnes, Giles S H Yeo, Stephen I O'Rahilly, Jørgen Jensen, Claudia Langenberg
Systemic proteome adaptions to 7-day complete caloric restriction in humans. Nature metabolism (2024)
Katie Duckett, Alice Williamson, John W R Kincaid, Kara M D Hunter, Laura J Corbin, Hilary C Martin, Ruth Y Eberhardt, Qin Qin Huang, Matthew E Hurles, Wen He, Raja Brauner, Angela Delaney, Leo Dunkel, Romina P Grinspon, Janet E Hall, Joel N Hirschhorn, Sasha R Howard, Ana C Latronico, Alexander A L Jorge, Ken McElreavey, Verónica Mericq, Paulina M Merino, Mark R Palmert, Lacey Plummer, Rodolfo A Rey, Raíssa C Rezende, Stephanie B Seminara, Kathryn Salnikov, Indraneel Banerjee, Brian Yee Hong Lam, John R B Perry, Nicholas John Timpson, Peter Ellis Clayton, Yee-Ming Chan, Ken K Ong, Stephen I O'Rahilly
Prevalence of deleterious variants in MC3R in patients with constitutional delay of growth and puberty. The Journal of clinical endocrinology and metabolism (2023)
Jake Peter Mann, Xiaowen Duan, Satish Patel, Luis Carlos Tábara, Fabio Scurria, Anna Alvarez-Guaita, Afreen Haider, Ineke Luijten, Matthew Page, Margherita Protasoni, Koini Lim, Samuel Virtue, Stephen I O'Rahilly, Martin Armstrong, Julien Prudent, Robert K Semple, David B Savage
A mouse model of human mitofusin 2-related lipodystrophy exhibits adipose-specific mitochondrial stress and reduced leptin secretion. eLife 12 (2023)
Alice Williamson, Dougall M Norris, Xianyong Yin, K Alaine Broadaway, Anne H Moxley, Swarooparani Vadlamudi, Emma P Wilson, Anne U Jackson, Vasudha Ahuja, Mette K Andersen, Zorayr Arzumanyan, Lori L Bonnycastle, Stefan R Bornstein, Maxi P Bretschneider, Thomas A Buchanan, Yi-Cheng Chang, Lee-Ming Chuang, Ren-Hua Chung, Tine D Clausen, Nis Peter Damm, Graciela E Delgado, Vanessa D de Mello, Josée Dupuis, Om Prakash Dwivedi, Michael R Erdos, Lilian Fernandes Silva, Timothy M Frayling, Christian Gieger, Mark O Goodarzi, Xiuqing Guo, Stefan Gustafsson, Liisa Hakaste, Ulf Hammar, Gad Hatem, Sandra Herrmann, Kurt Højlund, Katrin Horn, Willa A Hsueh, Yi-Jen Hung, Chii-Min Hwa, Anna Jonsson, Line L Kårhus, Marcus Edi Kleber, Peter Kovacs, Timo A Lakka, Marie Lauzon, I-Te Lee, Cecilia M Lindgren, Jaana Lindström, Allan Linneberg, Ching-Ti Liu, Jian'an Luan, Dina Mansour Aly, Elisabeth Mathiesen, Angela P Moissl, Andrew P Morris, Narisu Narisu, Nikolaos Perakakis, Annette Peters, Rashmi B Prasad, Roman N Rodionov, Kathryn Roll, Carsten F Rundsten, Chloe Sarnowski, Kai Savonen, Markus Scholz, Sapna Sharma, Sara E Stinson, Sufyan Suleman, Jingyi Tan, Kent D Taylor, Matti Uusitupa, Dorte Vistisen, Daniel R Witte, Romy Walther, Peitao Wu, Anny H Xiang, Björn Zethelius, null null, Emma Ahlqvist, Richard N Bergman, Yii-Der Ida Chen, Francis S Collins, Christoph Nowak, Jose C Florez, Andreas Fritsche, Harald Grallert, Leif C Groop, Torben Hansen, Heikki A Koistinen, Pirjo Komulainen, Markku Laakso, Lars Lind, Markus Loeffler, Winfried März, James B Meigs, Leslie J Raffel, Rainer Rauramaa, Jerome I Rotter, Peter E H Schwarz, Michael Stumvoll, Johan Sundström, Anke Tönjes, Tiinamaija Tuomi, Jaakko Tuomilehto, Robert Wagner, Inês A Barroso, Mark Walker, Niels Grarup, Michael Boehnke, Nicholas J Wareham, Karen L Mohlke, Eleanor Wheeler, Stephen I O'Rahilly, Daniel J Fazakerley, Claudia Langenberg
Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake. Nature genetics (2023)
Jake Peter Mann, Xiaowen Duan, Satish Patel, Luis Carlos Tábara, Fabio Scurria, Anna Alvarez-Guaita, Afreen Haider, Ineke Luijten, Matthew Page, Margherita Protasoni, Koini Lim, Samuel Virtue, Stephen I O'Rahilly, Martin Armstrong, Julien Prudent, Robert K Semple, David B Savage
A mouse model of human mitofusin-2-related lipodystrophy exhibits adipose-specific mitochondrial stress and reduced leptin secretion. eLife 12 (2023)
Jake Peter Mann, Xiaowen Duan, Satish Patel, Luis Carlos Tábara, Fabio Scurria, Anna Alvarez-Guaita, Afreen Haider, Ineke Luijten, Matthew Page, Margherita Protasoni, Koini Lim, Samuel Virtue, Stephen I O'Rahilly, Martin Armstrong, Julien Prudent, Robert K Semple, David B Savage
A mouse model of human mitofusin-2-related lipodystrophy exhibits adipose-specific mitochondrial stress and reduced leptin secretion. eLife 12 (2023)
Jake Peter Mann, Xiaowen Duan, Satish Patel, LuisCa C Tábara, Fabio Scurria, Anna Alvarez-Guaita, Afreen Haider, Ineke Luijten, Matthew Page, Margherita Protasoni, Koini Lim, Samuel Virtue, Stephen I O'Rahilly, Martin Armstrong, Julien Prudent, Robert K Semple, David B Savage
A mouse model of human mitofusin 2-related lipodystrophy exhibits adipose-specific mitochondrial stress and reduced leptin secretion. eLife 12 (2023)
Jake Peter Mann, Xiaowen Duan, Satish Patel, Luis Carlos Tábara, Fabio Scurria, Anna Alvarez-Guaita, Afreen Haider, Ineke Luijten, Matthew Page, Margherita Protasoni, Koini Lim, Samuel Virtue, Stephen I O'Rahilly, Martin Armstrong, Julien Prudent, Robert K Semple, David B Savage
A mouse model of human mitofusin-2-related lipodystrophy exhibits adipose-specific mitochondrial stress and reduced leptin secretion. eLife 12 (2023)
Jake Peter Mann, Xiaowen Duan, Satish Patel, Luis Carlos Tábara, Fabio Scurria, Anna Alvarez-Guaita, Afreen Haider, Ineke Luijten, Matthew Page, Margherita Protasoni, Koini Lim, Samuel Virtue, Stephen I O'Rahilly, Martin Armstrong, Julien Prudent, Robert K Semple, David B Savage
A mouse model of human mitofusin-2-related lipodystrophy exhibits adipose-specific mitochondrial stress and reduced leptin secretion. eLife 12 (2023)
Jake Peter Mann, Xiaowen Duan, Satish Patel, Luis Carlos Tábara, Fabio Scurria, Anna Alvarez-Guaita, Afreen Haider, Ineke Luijten, Matthew Page, Margherita Protasoni, Koini Lim, Samuel Virtue, Stephen I O'Rahilly, Martin Armstrong, Julien Prudent, Robert K Semple, David B Savage
A mouse model of human mitofusin-2-related lipodystrophy exhibits adipose-specific mitochondrial stress and reduced leptin secretion. eLife 12 (2023)
Jake Peter Mann, Xiaowen Duan, Satish Patel, Luis Carlos Tábara, Fabio Scurria, Anna Alvarez-Guaita, Afreen Haider, Ineke Luijten, Matthew Page, Margherita Protasoni, Koini Lim, Samuel Virtue, Stephen I O'Rahilly, Martin Armstrong, Julien Prudent, Robert K Semple, David B Savage
A mouse model of human mitofusin-2-related lipodystrophy exhibits adipose-specific mitochondrial stress and reduced leptin secretion. eLife 12 (2023)
Marlena S Fejzo, N Rocha, Irene Cimino, Sam M Lockhart, Clive J Petry, Richard G Kay, K Burling, P Barker, Amy L George, Nirmani Yasara, A Premawardhena, Sungsam Gong, E Cook, D Rimmington, K Rainbow, D J Withers, Victoria K Cortessis, P M Mullin, K W MacGibbon, E Jin, A Kam, Archie I Campbell, O Polasek, G Tzoneva, F M Gribble, G S H Yeo, B Y H Lam, Vladimir Saudek, I A Hughes, Ken K Ong, John R B Perry, A Sutton Cole, M Baumgarten, Paul I Welsh, Naveed Sattar, Gordon C S Smith, David Stephen Charnock-Jones, A P Coll, C L Meek, Sachith Mettananda, Caroline Hayward, Nicholas Mancuso, Stephen I O'Rahilly
GDF15 linked to maternal risk of nausea and vomiting during pregnancy. Nature (2023)
Stephen I O'Rahilly
Academic clinician-scientists risk becoming an endangered species. Nature medicine 29 (12) (2023)
Jake Peter Mann, Xiaowen Duan, Satish Patel, Luis Carlos Tábara, Fabio Scurria, Anna Alvarez-Guaita, Afreen Haider, Ineke Luijten, Matthew Page, Margherita Protasoni, Koini Lim, Samuel Virtue, Stephen I O'Rahilly, Martin Armstrong, Julien Prudent, Robert K Semple, David B Savage
A mouse model of human mitofusin-2-related lipodystrophy exhibits adipose-specific mitochondrial stress and reduced leptin secretion. eLife 12 (2023)
Stephen I O'Rahilly
Academic clinician-scientists risk becoming an endangered species. Nature medicine 29 (12) (2023)
Jake Peter Mann, Xiaowen Duan, Satish Patel, Luis Carlos Tábara, Fabio Scurria, Anna Alvarez-Guaita, Afreen Haider, Ineke Luijten, Matthew Page, Margherita Protasoni, Koini Lim, Samuel Virtue, Stephen I O'Rahilly, Martin Armstrong, Julien Prudent, Robert K Semple, David B Savage
A mouse model of human mitofusin-2-related lipodystrophy exhibits adipose-specific mitochondrial stress and reduced leptin secretion. eLife 12 (2023)
Jake Peter Mann, Xiaowen Duan, Satish Patel, Luis Carlos Tábara, Fabio Scurria, Anna Alvarez-Guaita, Afreen Haider, Ineke Luijten, Matthew Page, Margherita Protasoni, Koini Lim, Samuel Virtue, Stephen I O'Rahilly, Martin Armstrong, Julien Prudent, Robert K Semple, David B Savage
A mouse model of human mitofusin 2-related lipodystrophy exhibits adipose-specific mitochondrial stress and reduced leptin secretion. eLife 12 (2023)
Stephen I O'Rahilly
Academic clinician-scientists risk becoming an endangered species. Nature medicine 29 (12) (2023)
Jake Peter Mann, Xiaowen Duan, Satish Patel, Luis Carlos Tábara, Fabio Scurria, Anna Alvarez-Guaita, Afreen Haider, Ineke Luijten, Matthew Page, Margherita Protasoni, Koini Lim, Samuel Virtue, Stephen I O'Rahilly, Martin Armstrong, Julien Prudent, Robert K Semple, David B Savage
A mouse model of human mitofusin-2-related lipodystrophy exhibits adipose-specific mitochondrial stress and reduced leptin secretion. eLife 12 (2023)
Othman Al-Sawaf, Jakob Weiss, Marcin Skrzypski, Jie Min Lam, Takahiro Karasaki, Francisco Zambrana, Andrew C Kidd, Alexander M Frankell, Thomas B K Watkins, Carlos Martínez-Ruiz, Clare Puttick, James R M Black, Ariana Huebner, Maise Al Bakir, Mateo Sokač, Susie Collins, Selvaraju Veeriah, Neil Magno, Cristina Naceur-Lombardelli, Paulina Prymas, Antonia Toncheva, Sophia Ward, Nick Jayanth, Roberto Salgado, Christopher P Bridge, David Chistopher Christiani, Raymond H Mak, Camden Bay, Michael Rosenthal, Naveed Sattar, Paul I Welsh, Ying Liu, Norbert Perrimon, Karteek Popuri, Mirza Faisal Beg, Nicholas McGranahan, Allan Hackshaw, Danna M Breen, Stephen I O'Rahilly, Nicolai Juul Birkbak, Hugo J W L Aerts, null null, Mariam Jamal-Hanjani, Charles Swanton
Body composition and lung cancer-associated cachexia in TRACERx. Nature medicine (2023)
Yanislava Karusheva, Matthew Ratcliff, Alexander Mörseburg, Peter Barker, Audrey Melvin, Naveed Sattar, Keith Burling, Anna Backmark, Robert Roth, Lutz Jermutus, Esther Guiu-Jurado, Matthias Blüher, Paul I Welsh, Marko Hyvönen, Stephen I O'Rahilly
The Common H202D Variant in GDF-15 Does Not Affect Its Bioactivity but Can Significantly Interfere with Measurement of Its Circulating Levels. The journal of applied laboratory medicine 7 (6) (2022)
Stephen I O'Rahilly
"Treasure Your Exceptions"-Studying Human Extreme Phenotypes to Illuminate Metabolic Health and Disease: The 2019 Banting Medal for Scientific Achievement Lecture. Diabetes 70 (1) (2021)
Irene Cimino, Hanna Kim, Y C Loraine Tung, Kent Pedersen, Debra Rimmington, John A Tadross, Sara N Kohnke, Ana Neves Costa, André Barros, Stephanie Joaquim, Don Bennett, Audrey Melvin, Samuel M Lockhart, Anthony J Rostron, Jonathan Scott, Hui Liu, Keith Burling, Peter Barker, Menna R Clatworthy, E-Chiang Lee, A John Simpson, Giles S H Yeo, Luis Ferreira Moita, Kendra K Bence, Sebastian Beck Jørgensen, Anthony P Coll, Danna M Breen, Stephen I O'Rahilly
Activation of the hypothalamic-pituitary-adrenal axis by exogenous and endogenous GDF15. Proceedings of the National Academy of Sciences of the United States of America 118 (27) (2021)
Maik Pietzner, Eleanor Wheeler, Julia Carrasco-Zanini, Adrian Cortes, Mine Koprulu, Maria A Wörheide, Andreas Bender, James Cook, Isobel D Stewart, Nicola D Kerrison, Jian'an Luan, Johannes Raffler, Matthias Arnold, Wiebeke Arlt, Stephen I O'Rahilly, Gabi Kastenmüller, Eric R Gamazon, Aroon D Hingorani, Robert A Scott, Nicholas J Wareham, Claudia Langenberg
Mapping the proteo-genomic convergence of human diseases. Science (New York, N.Y.) 374 (6569) (2021)
Kaitlin H Wade, Brian Yee Hong Lam, Audrey Melvin, Warren Pan, Laura J Corbin, David A Hughes, Kara Rainbow, Jian-Hua Chen, Katie Duckett, Xiaoming Liu, Jacek Mokrosinski, Alexander Mörseburg, Sam Neaves, Alice Williamson, Chen Zhang, I Sadaf Farooqi, Giles S H Yeo, Nicholas John Timpson, Stephen I O'Rahilly
Loss-of-function mutations in the melanocortin 4 receptor in a UK birth cohort. Nature medicine 27 (6) (2021)
Brian Yee Hong Lam, Alice Williamson, Sarah Finer, Felix R Day, John A Tadross, A Gonçalves Soares, Kaitlin H Wade, P Sweeney, M N Bedenbaugh, Danielle T Porter, A Melvin, K L J Ellacott, R N Lippert, S Buller, J Rosmaninho-Salgado, G K C Dowsett, K E Ridley, Z Xu, Irene Cimino, D Rimmington, K Rainbow, K Duckett, Staffan Holmqvist, A Khan, X Dai, E G Bochukova, null null, R C Trembath, Hilary C Martin, A P Coll, David H Rowitch, Nicholas J Wareham, David A van Heel, Nicholas John Timpson, Richard B Simerly, Ken K Ong, Roger D Cone, Claudia Langenberg, John R B Perry, Giles S H Yeo, Stephen I O'Rahilly
MC3R links nutritional state to childhood growth and the timing of puberty. Nature 599 (7885) (2021)
Zhengzheng S Liang, Irene Cimino, Binnaz Yalcin, Narayanan Raghupathy, Valerie E Vancollie, Ximena Ibarra-Soria, Helen V Firth, Debra Rimmington, David R FitzPatrick, Christopher J Lelliott, Steven C Munger, Stephen I O'Rahilly, Anne C Ferguson-Smith, Anthony P Coll, Darren W Logan
Trappc9 deficiency causes parent-of-origin dependent microcephaly and obesity. PLoS genetics 16 (9) (2020)
Florent Serge Dye, Pierre Larraufie, Richard Kay, Tamana Darwish, Juraj Rievaj, Deborah A Goldspink, Claire L Meek, Stephen J Middleton, Richard H Hardwick, Geoffrey P Roberts, Jennifer L Percival-Alwyn, Tris Vaughan, Franco Ferraro, Benjamin G Challis, Stephen I O'Rahilly, Maria Groves, Fiona M Gribble, Frank Reimann
Characterisation of proguanylin expressing cells in the intestine - evidence for constitutive luminal secretion. Scientific reports 9 (1) (2019)
Yongjie Yang, Agatha A van der Klaauw, Liangru Zhu, Tessa M Cacciottolo, Yanlin He, Lukas K J Stadler, Chunmei Wang, Pingwen Xu, Kenji Saito, Antentor Hinton, Xiaofeng Yan, Julia M Keogh, Elana Henning, Matthew C Banton, Audrey E Hendricks, Elena G Bochukova, Vanisha Mistry, Katherine L Lawler, Lan Liao, Jianming Xu, Stephen I O'Rahilly, Qingchun Tong, null null, Inês A Barroso, Bert W O' Malley, David R FitzPatrick, Yong Xu
Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis. Nature communications 10 (1) (2019)
Laura J Corbin, Vanessa Y Tan, David A Hughes, Kaitlin H Wade, Dirk S Paul, Katherine E Tansey, Frances Butcher, Frank Dudbridge, Joanna M Howson, Momodou W Jallow, Catherine John, Nathalie Kingston, Cecilia M Lindgren, Michael C O'Donovan, Stephen I O'Rahilly, Michael J Owen, Colin Neil Alexander Palmer, Ewan R Pearson, Robert A Scott, David A van Heel, John Whittaker, Tim Frayling, Martin D Tobin, Louise V Wain, George Davey Smith, David M Evans, Fredrik Karpe, Mark I McCarthy, John Danesh, Paul W Franks, Nicholas J Timpson
Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference. Nature communications 9 (1) (2018)
John R Speakman, Ruth J F Loos, Stephen I O'Rahilly, J N Hirschhorn, D B Allison
GWAS for BMI: a treasure trove of fundamental insights into the genetic basis of obesity. International journal of obesity (2005) 42 (8) (2018)
Clive J Petry, Ken K Ong, Keith A Burling, Peter Barker, Sandra F Goodburn, John R B Perry, Carlo L Acerini, Ieuan A Hughes, Rebecca C Painter, Gijs B Afink, Professor David Dunger, Stephen I O'Rahilly
Associations of vomiting and antiemetic use in pregnancy with levels of circulating GDF15 early in the second trimester: A nested case-control study. Wellcome open research 3 (2018)
Nuno Rocha, Felicity Payne, Isabel Huang-Doran, Alison Sleigh, Katherine Fawcett, Claire Adams, Anna Stears, Vladimir Saudek, Stephen I O'Rahilly, Inês A Barroso, Robert K Semple
The metabolic syndrome- associated small G protein ARL15 plays a role in adipocyte differentiation and adiponectin secretion. Scientific reports 7 (1) (2017)
Rachel Larder, M F Michelle Sim, Pawan Gulati, Robin Antrobus, Y C Loraine Tung, Debra Rimmington, Eduard Ayuso, Joseph Polex-Wolf, Brian Y H Lam, Cristina Dias, Darren W Logan, Sam Virtue, Fatima Bosch, Giles S H Yeo, Vladimir Saudek, Stephen I O'Rahilly, Anthony P Coll
Obesity-associated gene TMEM18 has a role in the central control of appetite and body weight regulation. Proceedings of the National Academy of Sciences of the United States of America 114 (35) (2017)

Stephen I O'Rahilly.css-eqlu8i{font-size:small;padding-left:4px;} (Stephen O'Rahilly, S O'Rahilly)

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Stephen I O'Rahilly (Stephen O'Rahilly, S O'Rahilly)