Early-life factors are associated with waist circumference and type 2 diabetes among Ghanaian adults: The RODAM Study.
Ina DanquahJuliet AddoDaniel BoatengKerstin Klipstein-GrobuschKarlijn Anna Catharina MeeksCecilia GalbeteErik BeuneSilver BahendekaJoachim SprangerFrank P MockenhauptKarien StronksCharles AgyemangMatthias B SchulzeLiam SmeethPublished in: Scientific reports (2019)
Early-life experiences may fuel the emergence of obesity and type 2 diabetes among African populations. We evaluated childhood socio-economic status (SES) and childhood nutritional status as risk factors for increased waist circumference and type 2 diabetes among Ghanaian adults. In the multi-center, cross-sectional Research on Obesity and Diabetes among African Migrants (RODAM) Study, we calculated associations (adjusted for demographics and lifestyle) of parental education and anthropometric markers of childhood nutrition [leg length, leg length-to-height ratio (LHR)] with waist circumference and type 2 diabetes, respectively. Among 5,575 participants (mean age: 46.2 years; 62% female), lower education of either parent (vs. higher) was consistently associated with higher waist circumference (∆: 1.6-3.4 cm). Lower father's education tended to increase the odds of type 2 diabetes by 50% in women (95% confidence interval (CI): 1.0, 2.4). Reduced leg length and LHR were associated with higher waist circumference. But only in men, leg length was inversely related to type 2 diabetes (OR per 1 standard deviation decrease: 1.1; 95% CI: 1.0, 1.3). In this study, markers of poor childhood SES and early-life nutritional status relate to abdominal obesity in men and women and to type 2 diabetes in men. Thus, prevention efforts should start in early childhood.
Keyphrases
- type diabetes
- early life
- body mass index
- glycemic control
- weight gain
- body weight
- insulin resistance
- cardiovascular disease
- physical activity
- metabolic syndrome
- healthcare
- weight loss
- quality improvement
- cross sectional
- mental health
- skeletal muscle
- body composition
- childhood cancer
- pregnancy outcomes
- breast cancer risk