A polymorphism in ABCA2 is associated with neutropenia induced by capecitabine in Japanese patients with colorectal cancer.

Yukitaka ShibataNatsumi MatsumotoRemi MuraseYutaro KubotaHiroo IshidaKen ShimadaKen-Ichi Fujita

Published in: Cancer chemotherapy and pharmacology (2023)

We found that ABCA2 polymorphism was significantly associated with systemic exposure to capecitabine and capecitabine-induced neutropenia in Japanese patients with CRC.

Keyphrases

phase ii study
locally advanced
metastatic breast cancer
metastatic colorectal cancer
phase iii
chemotherapy induced
rectal cancer
high glucose
open label
drug induced
diabetic rats
clinical trial
randomized controlled trial
oxidative stress