Mast cells-derived MiR-223 destroys intestinal barrier function by inhibition of CLDN8 expression in intestinal epithelial cells.

Musheng LiJunhong ZhaoMeiwan CaoRuitao LiuGuanhua ChenSongyu LiYuanwen XieJing XieYang ChengLing HuangMingmin SuYuxin XuMingyue ZhengKejian ZouLanlan GengWanfu XuSitang Gong

Published in: Biological research (2020)

These results indicated that enrichment of exosomal miR-223 from HMCs-1 inhibited CLDN8 expression, leading to destroy intestinal barrier function. These finding provided a novel insight of MCs as a new target for therapeutic treatment of IBD.

Keyphrases

poor prognosis
long non coding rna
cell proliferation
long noncoding rna
binding protein