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Mutation of the Cell Cycle Regulator p27kip1 Drives Pseudohypoxic Pheochromocytoma Development.

Hermine MohrSimone BallkeNicole BechmannSebastian GuldeJaber Malekzadeh-NajafabadiMirko PeitzschVasilis NtziachristosKatja SteigerTobias WiedemannNatalia S Pellegata
Published in: Cancers (2021)
Endogenous rat PCCs recapitulate key phenotypic features of human p-PPGLs. Thus, MENX rats emerge as the best available animal model of these aggressive tumors. Our study provides evidence of a link between cell cycle dysregulation and pseudohypoxia.
Keyphrases
  • cell cycle
  • cell proliferation
  • endothelial cells
  • oxidative stress
  • induced pluripotent stem cells
  • pluripotent stem cells