Mutation of the Cell Cycle Regulator p27kip1 Drives Pseudohypoxic Pheochromocytoma Development.

Hermine MohrSimone BallkeNicole BechmannSebastian GuldeJaber Malekzadeh-NajafabadiMirko PeitzschVasilis NtziachristosKatja SteigerTobias WiedemannNatalia S Pellegata

Published in: Cancers (2021)

Endogenous rat PCCs recapitulate key phenotypic features of human p-PPGLs. Thus, MENX rats emerge as the best available animal model of these aggressive tumors. Our study provides evidence of a link between cell cycle dysregulation and pseudohypoxia.

Keyphrases

cell cycle
cell proliferation
endothelial cells
oxidative stress
induced pluripotent stem cells
pluripotent stem cells