CRISPR Interference-Mediated Silencing of the mmpL3 Gene in Mycobacterium smegmatis and Its Impact on Antimicrobial Susceptibility.

Yonita YulianiAzizah Fitriana Nurul IlmiSuthidee PetsongAjcharaporn SawatpanichSunisa ChirakulTanittha ChatsuwanTanapat PalagaSuwatchareeporn Rotcheewaphan

Published in: Antibiotics (Basel, Switzerland) (2024)

, resulting in growth deficiencies and resensitization to certain antimicrobial agents. The impact was dependent upon the level of gene expression.

Keyphrases

gene expression
genome wide
dna methylation
mycobacterium tuberculosis
copy number
staphylococcus aureus
genome editing
crispr cas
genome wide identification