Intake of oligoelements with cytarabine or etoposide alters dopamine levels and oxidative damage in rat brain.
David Calderón GuzmánNorma Osnaya BrizuelaMaribel Ortíz HerreraHugo Juárez OlguínArmando Valenzuela PerazaNorma Labra RuízGerardo Barragán MejíaPublished in: Scientific reports (2024)
Research on the relationships between oligoelements (OE) and the development of cancer or its prevention is a field that is gaining increasing relevance. The aim was to evaluate OE and their interactions with oncology treatments (cytarabine or etoposide) to determine the effects of this combination on biogenic amines and oxidative stress biomarkers in the brain regions of young Wistar rats. Dopamine (DA), 5-Hydroxyindoleacetic acid (5-Hiaa), Glutathione (Gsh), Tiobarbituric acid reactive substances (TBARS) and Ca +2 , Mg +2 ATPase enzyme activity were measured in brain regions tissues using spectrophometric and fluorometric methods previously validated. The combination of oligoelements and cytarabine increased dopamine in the striatum but decreased it in cerebellum/medulla-oblongata, whereas the combination of oligoelements and etoposide reduced lipid peroxidation. These results suggest that supplementation with oligoelements modifies the effects of cytarabine and etoposide by redox pathways, and may become promising therapeutic targets in patients with cancer.
Keyphrases
- acute myeloid leukemia
- high dose
- uric acid
- oxidative stress
- resting state
- white matter
- prefrontal cortex
- low dose
- palliative care
- gene expression
- functional connectivity
- cerebral ischemia
- metabolic syndrome
- fatty acid
- drinking water
- mass spectrometry
- signaling pathway
- fluorescent probe
- brain injury
- molecularly imprinted
- endoplasmic reticulum
- heat stress