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Dapsone-induced agranulocytosis: symptoms may alert more reliably than the current blood monitoring protocol.

K St ClaireS KaulE G CalditoO N KramerT GriffinJoerg Albrecht
Published in: The British journal of dermatology (2021)
Although dapsone is generally a safe and effective medication, agranulocytosis is a serious concern. Agranulocytosis is rare, idiosyncratic, and generally presents within the first 3 months of treatment with an absolute neutrophil count less than 500/microliter.1 Currently a complete blood count (CBC) with differential every week for the first month, followed by monthly for 6 months and then biannually is recommended during dapsone therapy.
Keyphrases
  • drug induced
  • randomized controlled trial
  • high glucose
  • healthcare
  • diabetic rats
  • oxidative stress
  • sleep quality
  • depressive symptoms
  • study protocol
  • placebo controlled