Photobiomodulation minimizes taste changes during hematopoietic cell transplantation: A randomized clinical trial.
Mariana Henriques FerreiraLeticia Mello BezinelliFernanda de Paula EduardoAndrea Z PereiraNelson HammerschlakLuciana CorrêaPublished in: Journal of biophotonics (2024)
Prevention and treatment protocols for taste changes observed during hematopoietic cell transplantation (HCT) are not well-established. The purpose of this study was to assess the efficacy of photobiomodulation (PBM) in relieving taste changes and preventing lingual papillae atrophy. HCT patients received PBM (n = 42) on the tongue dorsum using an InGaAIP laser (660 nm, 100 mW, 1.1 W/cm 2 , 8.8 J/cm 2 ). During the HCT conditioning (T0), severe neutropenia (T1), and after neutrophil engraftment (T2), taste acuity for sweet, bitter, sour, and salty solutions, and clinical appearance of lingual papillae were compared with those of a placebo group (n = 43). PBM significantly reduced hypogeusia, ageusia, and parageusia at T1 and T2, and also successfully prevented papillae atrophy during all the analyzed HCT periods. In conclusion, PBM enhanced taste acuity during HCT. The decrease in papillae atrophy indicated a potential regenerative effect of this therapy on tongue mucosa.
Keyphrases
- cell cycle arrest
- end stage renal disease
- stem cells
- ejection fraction
- cell death
- chronic kidney disease
- mesenchymal stem cells
- pi k akt
- prognostic factors
- randomized controlled trial
- peritoneal dialysis
- wound healing
- early onset
- patient reported outcomes
- cell proliferation
- signaling pathway
- climate change
- mass spectrometry
- risk assessment
- high speed
- chemotherapy induced