The landscape of cell-free mitochondrial DNA in liquid biopsy for cancer detection.

Ymke van der PolNorbert MoldovanJip RamakerSanne BootsmaKristiaan J LenosLouis VermeulenShahneen SandhuIdris BahceD Michiel PegtelStephen Q WongSarah-Jane Dawson Dineika Chandrananda Florent Mouliere

Published in: Genome biology (2023)

The mtDNA signal retrieved by whole genome sequencing has the potential to boost the detection of cancer when combined with other tumor-derived signals in liquid biopsies.

Keyphrases

mitochondrial dna
cell free
copy number
papillary thyroid
loop mediated isothermal amplification
ionic liquid
real time pcr
ultrasound guided
label free
lymph node metastasis
squamous cell carcinoma
gene expression
dna methylation
genome wide
climate change
human health