P-Selectin Glycoprotein Ligand-1 Deficiency Protects Against Aortic Aneurysm Formation Induced by DOCA Plus Salt.

Xianxian WuXing LiuHang YangQianlong ChenNa ZhangYuhan LiXingchen DuXue LiuXiaoliang JiangYideng JiangZhou ZhouZhiwei Yang

Published in: Cardiovascular drugs and therapy (2021)

PSGL-1 deficiency is protective against inflammatory cells migration and recruitment in the condition of AA through attenuation of leukocyte-endothelial adhesion. Inhibition of PSGL-1 may be a potential therapeutic target for the prevention and treatment of human AA.

Keyphrases

aortic aneurysm
endothelial cells
induced apoptosis
replacement therapy
cell cycle arrest
pluripotent stem cells
endoplasmic reticulum stress
peripheral blood
biofilm formation
signaling pathway
cystic fibrosis