A meta-analysis of methotrexate polyglutamates in relation to efficacy and toxicity of methotrexate in inflammatory arthritis, colitis and dermatitis.

Maartje M van de MeebergRenske C F HebingMichael T NurmohamedHerma H FidderMartijn W HeymansGerd BoumaMarjolein S de Bruin-WellerJanneke TekstraBart van den BemtRobert de JongeMaja Bulatović Ćalasan

Published in: British journal of clinical pharmacology (2022)

We showed that higher concentrations of erythrocyte MTX-PG were associated with lower disease activity in RA, JIA and psoriasis. These findings are an important step towards implementation of TDM for MTX treatment across IMIDs.

Keyphrases

disease activity
rheumatoid arthritis
juvenile idiopathic arthritis
systemic lupus erythematosus
rheumatoid arthritis patients
ankylosing spondylitis
high dose
oxidative stress
primary care
healthcare
atopic dermatitis
interstitial lung disease
systemic sclerosis