Sinomenine Inhibits the Growth of Ovarian Cancer Cells Through the Suppression of Mitosis by Down-Regulating the Expression and the Activity of CDK1.

Xiaoyan QuBing Yu Meng-Mei ZhuXiaomei LiLishan MaChuyin LiuYixing ZhangZhongping Cheng

Published in: OncoTargets and therapy (2021)

Our results demonstrated that sinomenine inhibited the proliferation of HeyA8 cells through suppressing mitosis by down-regulating the expression and the activity of CDK1. The study may provide a preliminary research basis for the application of sinomenine in anti-ovarian cancer.

Keyphrases

poor prognosis
signaling pathway
induced apoptosis
cell cycle
cell cycle arrest
binding protein
long non coding rna
cell death
cell proliferation
pi k akt