Sex hormone-binding globulin and risk of fracture in older adults: systematic review and meta-analysis of observational studies.

Khemayanto HidayatX DuB-M Shi

Published in: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2018)

The present meta-analysis suggests that higher SHBG levels predict an increased risk of fracture in older adults. Further studies should aim to elucidate the complex biological mechanisms by which SHBG may affect fracture risk.

Keyphrases

systematic review
meta analyses
physical activity
hip fracture
case control
randomized controlled trial
dna binding