Potential Impact of Sex and BMI on Response to Therapy in Psoriatic Arthritis: Post Hoc Analysis of Results From the SEAM-PsA Trial.
Phillip J MeaseDafna D GladmanJoseph Frank MerolaAtul DeodharPhilip S HelliwellDavid H CollierLyrica LiuArthur KavanaughPublished in: The Journal of rheumatology (2022)
Improved outcomes were observed more in men than in women for MDA and PASDAS with MTX+ETN combination therapy. Patients with BMI ≤ 30 had better outcomes than those with BMI > 30, with no clear pattern regarding treatment received. These findings suggest that contextual factors such as sex and BMI may affect response to PsA therapy.
Keyphrases
- combination therapy
- body mass index
- prostate cancer
- weight gain
- clinical trial
- polycystic ovary syndrome
- study protocol
- type diabetes
- randomized controlled trial
- stem cells
- cell therapy
- cell proliferation
- cell death
- mesenchymal stem cells
- insulin resistance
- climate change
- pregnancy outcomes
- glycemic control
- cell cycle arrest