Gene Polymorphisms of the Renin-Angiotensin System and Bleeding Complications of Warfarin: Genetic-Based Machine Learning Models.
Joo-Hee KimJeong YeeByung-Chul ChangHye Sun GwakPublished in: Pharmaceuticals (Basel, Switzerland) (2021)
This study demonstrated that RAS-related polymorphisms, including the H2 haplotype of the ACE gene, could affect bleeding complications during warfarin treatment for patients with mechanical heart valves. Our results could be used to develop individually tailored intervention strategies to prevent warfarin-induced bleeding.
Keyphrases
- atrial fibrillation
- direct oral anticoagulants
- oral anticoagulants
- machine learning
- heart failure
- genome wide
- venous thromboembolism
- randomized controlled trial
- copy number
- high glucose
- drug induced
- artificial intelligence
- aortic valve replacement
- smoking cessation
- transcription factor
- left ventricular
- transcatheter aortic valve replacement
- aortic stenosis